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- Title
Biomechanical properties: effects of low-level laser therapy and Biosilicate on tibial bone defects in osteopenic rats.
- Authors
Fangel, Renan; Bossini, Paulo S.; Renno, Ana Cláudia; Granito, Renata N.; Wang, Charles C.; Nonaka, Keico O.; Driusso, Patricia; Parizotto, Nivaldo A.; Oishi, Jorge
- Abstract
Purpose: The aim of this study was to investigate the effects of laser therapy and Biosilicate® on the biomechanical properties of bone callus in osteopenic rats. Methods: Fifty female Wistar rats were equally divided into 5 groups (n=10/group): osteopenic rats with intact tibiae (SC); osteopenic rats with unfilled and untreated tibial bone defects (OC); osteopenic rats whose bone defects were treated with Biosilicate® (B); osteopenic rats whose bone defects were treated with 830-nm laser, at 120 J/cm2 (L120) and osteopenic rats whose bone defects were treated with Biosilicate® and 830-nm laser, at 120 J/cm2 (BL120). Ovariectomy (OVX) was used to induce osteopenia. A non-critical bone defect was created on the tibia of the osteopenic animals 8 weeks after OVX. In Biosilicate® groups, bone defects were completely filled with the biomaterial. For the laser therapy, an 830-nm laser, 120 J/cm2 was used. On day 14 postsurgery, rats were euthanized, and tibiae were removed for biomechanical analysis. Results: Maximal load and energy absorption were higher in groups B and BL120, according to the indentation test. Animals submitted to low-level laser therapy (LLLT) did not show any significant biomechanical improvement, but the association between Biosilicate® and LLLT was shown to be efficient to enhance callus biomechanical properties. Conversely, no differences were found between study groups in the bending test. Conclusions: Biosilicate® alone or in association with low level laser therapy improves biomechanical properties of tibial bone callus in osteopenic rats.
- Subjects
MECHANICAL properties of biological membranes; LASER therapy; SILICATES; RATS; BONE cells
- Publication
Journal of Applied Biomaterials & Functional Materials, 2014, Vol 12, Issue 3, p271
- ISSN
2280-8000
- Publication type
Article
- DOI
10.5301/jabfm.5000198