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- Title
No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations.
- Authors
Young Ju Kim; Bo Hyun Park; Hyesook Park; Sung-Chul Jung; Myung-Geol Pang; Hun-Mee Ryu; Kwang-Soo Lee; Sang-Mi Eom; Hyun-Young Park; Kim, Young Ju; Park, Bo Hyun; Park, Hyesook; Jung, Sung-Chul; Pang, Myung-Geol; Ryu, Hyun-Mee; Lee, Kwang-Soo; Eom, Sang-Mi; Park, Hyun-Young
- Abstract
The purpose of this study was to investigate whether there is any association between preeclampsia and eNOS, DDAH, and VEGF gene polymorphisms, and also to search for a possible association between haplotypes in eNOS, DDHA, and VEGF genes and the risk for preeclampsia. DNA was extracted from whole blood of 223 preeclampsia patients and 237 healthy pregnant women. The genotypes were analyzed by a single base primer extension assay using a SNaPShot assay kit. Results were analyzed with the Student's t-test, Chi-square test, and Logistic regression analysis. Haplotype analyses were performed using Haploview 3.2 version. There were no significant differences in genotype or allele frequencies of eNOS, DDAH, and VEGF gene polymorphisms between preeclampsia patients and controls. No increase in the risk of preeclampsia for those genes was observed under any model of inheritance and there were no statistically significant associations between any haplotypes and preeclampsia risk. Polymorphisms in eNOS, DDAH, and VEGF gene do not seem to be risk factors for preeclampsia.
- Subjects
KOREA; PREECLAMPSIA; GENETIC polymorphisms; VASCULAR endothelial growth factors; PREGNANT women; KOREANS; AMIDASES; ASIANS; COMPARATIVE studies; GENES; RESEARCH methodology; MEDICAL cooperation; OXIDOREDUCTASES; RESEARCH; EVALUATION research; RETROSPECTIVE studies; CASE-control method; HAPLOTYPES; GENOTYPES
- Publication
Twin Research & Human Genetics, 2008, Vol 11, Issue 1, p77
- ISSN
1832-4274
- Publication type
journal article
- DOI
10.1375/twin.11.1.77