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- Title
Nuclear pore complex remodeling by p75<sup>NTR</sup> cleavage controls TGF-β signaling and astrocyte functions.
- Authors
Schachtrup, Christian; Ryu, Jae Kyu; Mammadzada, Könül; Khan, Abdullah S; Carlton, Peter M; Perez, Alex; Christian, Frank; Le Moan, Natacha; Vagena, Eirini; Baeza-Raja, Bernat; Rafalski, Victoria; Chan, Justin P; Nitschke, Roland; Houslay, Miles D; Ellisman, Mark H; Wyss-Coray, Tony; Palop, Jorge J; Akassoglou, Katerina
- Abstract
Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75NTR) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75NTR interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75NTR controls astrocyte-neuronal communication in response to profibrotic factors.
- Subjects
NUCLEAR pore complex; NEUROTROPHIN receptors; TRANSFORMING growth factors; ASTROCYTES; NUCLEOCYTOPLASMIC interactions
- Publication
Nature Neuroscience, 2015, Vol 18, Issue 8, p1077
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.4054