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- Title
Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.
- Authors
Verweij, Niek; Leach, Irene Mateo; Isaacs, Aaron; Arking, Dan E.; Bis, Joshua C.; Pers, Tune H.; Van Den Berg, Marten E.; Lyytikäinen, Leo-Pekka; Barnett, Phil; Xinchen Wang; Soliman, Elsayed Z.; Van Duijn, Cornelia M.; Kähönen, Mika; Van Veldhuisen, Dirk J.; Kors, Jan A.; Raitakari, Olli T.; Silva, Claudia T.; Lehtimäki, Terho; Hillege, Hans L.; Hirschhorn, Joel N.
- Abstract
The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype-phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying the phenotypes, including genes with established roles in the cardiac repolarization phase (SCN5A/SCN10A, KCND3, KCNB1, NOS1AP and HEY2) and others with as yet undefined cardiac function. These associations may provide insights in the spatiotemporal contribution of genetic variation influencing cardiac repolarization and provide novel leads for future functional follow-up.
- Publication
Human Molecular Genetics, 2016, Vol 25, Issue 10, p2093
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddw058