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- Title
Inter-α-Inhibitor (│α│) Concentration in Pig Plasma Is Independent of Acute Phase Protein Response.
- Authors
Carrette, Odile; Mizon, Charlotte; Marquette, Charles Hugo; Lampreave, Fermin; Mizon, Jacques
- Abstract
Human inter-a-inhibitor (│α│) has been shown to exert a beneficial therapeutic effect in a porcine model of endotoxin shock. It is therefore useful to have a better understanding of IaI metabolism during severe inflammatory syndromes. Experimental bacterial pneumonia was induced in pigs. The acute phase response was highlighted by an increase in pig major acute phase protein (pig-MAP) and haptoglobin concentrations in plasma collected daily over 4 days. In the same samples, the IaI levels remained unchanged. Moreover, crossed-immunoelectrophoretic and immunoblot analyses did not show any qualitative modification of │α│ throughout the experiment. │α│ has been reported to be a negative acute phase protein in both humans and rats. Here we demonstrated that IaI behavior clearly differs in humans and pigs and is definitively species specific.
- Publication
Clinical Chemistry & Laboratory Medicine, 1999, Vol 37, Issue 5, p521
- ISSN
1434-6621
- Publication type
Article