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- Title
Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.
- Authors
Häyry, V.; Mäkinen, L. K.; Atula, T.; Sariola, H.; Mäkitie, A.; Leivo, I.; Keski-Säntti, H.; Lundin, J.; Haglund, C.; Hagström, J.; Häyry, V; Mäkinen, L K; Mäkitie, A; Keski-Säntti, H; Hagström, J
- Abstract
<bold>Background: </bold>The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epithelial-mesenchymal transition. The expression of these markers has been connected to prognosis in many cancer types.<bold>Methods: </bold>Bmi-1, c-myc, and Snail expressions were studied in our material consisting of 73 primarily T1N0M0 oral tongue carcinoma patients. We compared the immunoexpressions of Bmi-1, c-myc, and Snail with clinical parameters including the degree of histological differentiation, tumour size, TNM classification, depth of invasion, and resection margins. In addition, survival analyses were performed, comparing disease-free survival time with the registered protein expression of the markers mentioned above.<bold>Results: </bold>A significant correlation between Bmi-1 protein expression and recurrence (log-rank test, P=0.005) was detected. Snail and c-myc expression did not correlate with prognosis. Snail expression correlated with histopathological grade (Fisher's exact test, P=0.007) and with the invasion depth of tumours (chi(2)-test, P=0.037).<bold>Conclusion: </bold>Negative Bmi-1 immunoexpression might serve as a marker of poor prognosis in oral tongue carcinoma patients.
- Subjects
GENE expression; SQUAMOUS cell carcinoma; APOPTOSIS; CELL death; CELL growth; CELL proliferation; PROGNOSIS; PROTEIN metabolism; CANCER relapse; COMPARATIVE studies; IMMUNOENZYME technique; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SURVIVAL; TRANSCRIPTION factors; TONGUE tumors; EVALUATION research; NUCLEAR proteins; TISSUE arrays
- Publication
British Journal of Cancer, 2010, Vol 102, Issue 5, p892
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605544