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- Title
Similarity of cutaneous reactive hyperemia in the forearm of women with and without hyperinsulinemia.
- Authors
Seywert, A.-J.; Kubli, S.; Giusti, V.; Feihl, F.; Waeber, B.; Tappy, L.
- Abstract
OBJECTIVE:: The present study was undertaken to assess in pre- and postmenopausal women whether obesity influences cutaneous reactive hyperemia in the forearm. DESIGN:: Cross-sectional study. SUBJECTS AND METHODS:: Eight lean premenopausal (age 24.6±3.5?y, BMI=21.9±1.5?kg/m2, mean±1?s.d.), eight obese premenopausal (age 27.8±5.1?y, BMI=35.3±5.8?kg/m2), eight lean postmenopausal (age 56.1±8.3?y, BMI=20.2±2.2?kg/m2) and eight obese postmenopausal women (age 57.4±6.1?y, BMI=32.8±3?kg/m2) were included. Plasma glucose, insulin and lipid profile were determined in fasting state, and a glucose tolerance test was performed. The skin blood flow response to transient occlusion of the forearm circulation (reactive hyperemia, RH) was measured using a laser-Doppler imaging system. RESULTS:: Obese women had hyperinsulinemia, suggesting that they were insulin-resistant. The magnitude of the RH was similar in postmenopausal compared to premenopausal women. Obesity did not influence this microvascular response. CONCLUSION:: Obesity, which is known to be associated with impaired endothelial-dependent vasodilation in the skeletal musculature, has no effect on the RH of the forearm skin microcirculation.International Journal of Obesity (2004) 28, 611-615. doi:10.1038/sj.ijo.0802587 Published online 3 February 2004
- Subjects
OBESITY; HYPEREMIA; YOUNG women; MIDDLE-aged women; LEANNESS; INSULIN resistance; FOREARM
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2004, Vol 28, Issue 4, p611
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0802587