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- Title
An evidence synthesis approach to estimating Hepatitis C Prevalence in England and Wales.
- Authors
De Angelis, D.; Sweeting, M.; Ades, A. E.; Hickman, M.; Hope, V.; Ramsay, M.
- Abstract
In England and Wales, routine monitoring has been consistently showing an increase in mortality and morbidity due to infection with the Hepatitis C Virus (HCV). However, the magnitude of the underlying epidemic is still the subject of debate. In this paper we present estimates of the number of individuals aged 15-59 chronically infected with HCV in 2003, derived from a Bayesian synthesis of information available from multiple sources on the size of the groups at risk for HCV and the risk specific anti-HCV prevalence. Results show that the number of chronic infections is of the order of 142,000 (95% CrI: 90,000, 231,000), with the majority (85%, 95% CrI: 74%, 93%) in injecting drug users and about 80% (95% CrI: 74%, 84%) in the age group 15-44.
- Subjects
WALES; ENGLAND; HEPATITIS C virus; HEPATITIS C; ESTIMATION theory; MATHEMATICAL statistics
- Publication
Statistical Methods in Medical Research, 2009, Vol 18, Issue 4, p361
- ISSN
0962-2802
- Publication type
Article
- DOI
10.1177/0962280208094691