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- Title
Pregnancy outcome in survivors of advanced Hodgkin disease.
- Authors
Janov, Abbe J.; Anderson, James; Cella, David F.; Zuckerman, Enid; Kornblith, Alice B.; Holland, Jimmie C.; Kanfor, Arlene F.; Li, Frederick P.; Janov, A J; Anderson, J; Cella, D F; Zuckerman, E; Kornblith, A B; Holland, J C; Kantor, A F; Li, F P; Henderson, E; Weiss, R B
- Abstract
<bold>Background: </bold>Pregnancy outcome was reported by 139 survivors of advanced Hodgkin disease treated on nine protocols of Cancer and Leukemia Group B from 1966 to 1986.<bold>Methods: </bold>These patients provided data on 302 singleton pregnancies of a duration of at least 20 weeks that occurred before, during, or after treatment for Hodgkin disease (252, 26, and 24 pregnancies, respectively).<bold>Results: </bold>There were 4 perinatal deaths, as compared with 5.7 expected. Cancer subsequently developed in 2 offspring (expected, 1.2). However, 22 newborn infants had low a birth weight, exceeding the expected number of 13.7 (relative risk 1.6; 95% confidence interval, 1.0-2.4). The excess number of low weight births occurred primarily during the period of Hodgkin disease diagnosis and treatment but is based on small numbers.<bold>Conclusion: </bold>No increase in adverse outcome occurred in pregnancies that antedated the development of Hodgkin disease.
- Publication
Cancer (0008543X), 1992, Vol 70, Issue 3, p688
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19920801)70:3<688::AID-CNCR2820700325>3.0.CO;2-V