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- Title
A clinicopathologic study of primary hepatic carcinoid tumors.
- Authors
Andreola, Salvatore; Lombardi, Luciano; Audisio, Riccardo A.; Mazzaferro, Vincenzo; Doci, Roberto; Gennari, Leandro; Koukouras, Dimitris; Makowka, Leonard; Starzl, Thomas E.; Van Thiel, David H.; Andreola, S; Lombardi, L; Audisio, R A; Mazzaferro, V; Koukouras, D; Doci, R; Gennari, L; Makowka, L; Starzl, T E; van Thiel, D H
- Abstract
Six cases of primary hepatic carcinoid tumors were studied with combined immunocytochemical and electron microscopic techniques. Positive tumor immunostaining with PHE5, LK2H10, neuron-specific enolase (NSE), serotonin, gastrin, and insulin antibodies was observed. At the ultrastructural level, cytoplasmic dense granules were seen in all the cases tested. This finding supports a putative origin of these carcinoids found in the liver from a pluripotential stem cell. The clinical course and follow-up of these cases suggests that this unusual hepatic neoplasm has a more favorable prognosis than other forms of hepatic cancer.
- Publication
Cancer (0008543X), 1990, Vol 65, Issue 5, p1211
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19900301)65:5<1211::AID-CNCR2820650530>3.0.CO;2-M