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- Title
GSTT1 and GSTM1 Null Genotypes May Facilitate Hepatitis C Virus Infection Becoming Chronic.
- Authors
Martínez, Carmen; García-Martín, Elena; Ladero, José M.; Herráez, Oscar; Ortega, Luis; Taxonera, Carlos; Suárez, Avelina; Díaz-Rubio, Manuel; Agúndez, José A. G.
- Abstract
Oxidative stress contributes to hepatitis C virus (HCV)—induced liver damage. The activity of antioxidant glutathione S-transferases (GSTs) T1 and M1 is polymorphic. The GSTT1 and GSTM1 genotypes were identified in 139 HCV-infected patients and in 329 healthy individuals. Among patients, there was an excess of GSTT1 (odds ratio [OR], 2.76 [95% confidence interval {CI}, 1.77-4.30]; P<.001 ) and GSTM1 (OR, 1.54 [95% CI, 1.02-2.35]; P = .032) null genotypes and of double-null haplotypes (OR, 3.65 [95% CI, 1.98-6.75]; P<.001). The GSTT1 null genotype, particularly if associated with the GSTM1 null genotype, may facilitate HCV infection becoming chronic.
- Subjects
HEPATITIS C virus; GLUTATHIONE transferase; CHRONIC active hepatitis; GENETIC polymorphisms; CHRONIC diseases; VIRAL hepatitis; OXIDATIVE stress; GENETIC research
- Publication
Journal of Infectious Diseases, 2007, Vol 195, Issue 9, p1320
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/513569