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- Title
No Difference in Clinical Progression between Patients Infected with the Predominant Human Immunodeficiency Virus Type 1 Circulating Recombinant Form (CRF) 02_AG Strain and Patients Not Infected with CRF02_AG, in Western and ...
- Authors
Laurent, Christian; Bourgeois, Anke; Faye, Mame Awa; Mougnutou, Rose; Seydi, Moussa; Gueye, Mandoumbé; Liégeois, Florian; Kane, Coumba Touré; Butel, Christelle; Mbuagbaw, Josephine; Zekeng, Léopold; Mboup, Souleymane; Mpoudi-Ngolé, Eitel; Peeters, Martine; Delaporte, Eric
- Abstract
To compare human immunodeficiency virus (HIV) type 1 disease progression in patients infected by the predominant strain circulating recombinant form (CRF) 02AG in western and west-central Africa and in patients infected by other strains, a prospective multicenter cohort study was conducted in Cameroon and Senegal. Among the 335 patients, a broad HIV-1 group M subtype diversity was observed in the envelope V3-V5 region, but strain CRF02AG predominated in both Cameroon and Senegal (61.2% and 62.9%, respectively; P < .8). Multivariate analyses showed no difference between patients infected by CRF02 strains and those infected by other strains in terms of survival (adjusted hazards ratio [HR], 1.16; 95% confidence interval [CI], 0.76-1.78; P = .5), clinical disease progression (HR, 0.79; 95% CI, 0.50-1.25; P = .3), or square root CD4 cell decline (regression coefficient, -0.01; 95% CI, -0.82 to 0.81; P = .9). This study suggests that the predominance of HIV-1 CRF02AG strain in western and west-central Africa should have no major clinical consequences.
- Subjects
AFRICA; HIV-positive persons; SEXUALLY transmitted diseases
- Publication
Journal of Infectious Diseases, 2002, Vol 186, Issue 4, p486
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/341833