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- Title
Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine.
- Authors
Chan, Thomas; Cheung, Carol; Yeung, Ian; Hwang, Yu-Yan; Gill, Harinder; Wong, Ian; Kwong, Yok-Lam
- Abstract
Cytomegalovirus (CMV) retinitis is exceptionally rare outside the clinical context of acquired immunodeficiency syndrome and organ allografting. In a population where seropositivity for past CMV infection exceeded 90 %, CMV retinitis was observed in five of 138 patients (3.6 %) receiving fludarabine-containing regimens together with rituximab, which was significantly more frequent than in 141 patients receiving fludarabine-containing regimens alone, where no case was observed ( P = 0.029). Treatment of CMV retinitis comprised both intravitreal and systemic ganciclovir/foscarnet. Upon recovery, secondary retinal atrophy occurred in all patients, leading to blindness in 86 % of affected eyes. CMV retinitis is an important complication in patients receiving concomitant rituximab and fludarabine-containing regimens.
- Subjects
CYTOMEGALOVIRUS retinitis treatment; RITUXIMAB; FLUDARABINE; COMBINATION drug therapy; AIDS; HOMOGRAFTS
- Publication
Annals of Hematology, 2015, Vol 94, Issue 6, p1043
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-014-2296-5