We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Diagnosis of subtle focal dysplastic lesions: curvilinear reformatting from three-dimensional magnetic resonance imaging.
- Authors
Bastos, Alexandre C.; Comeau, Roch M.; Andermann, Frederick; Melanson, Denis; Cendes, Fernando; Dubeau, Francois; Fontaine, Suzanne; Tampieri, Donatella; Olivier, Andre; Bastos, A C; Comeau, R M; Andermann, F; Melanson, D; Cendes, F; Dubeau, F; Fontaine, S; Tampieri, D; Olivier, A
- Abstract
Focal cortical dysplasia is a frequent cause of medically intractable partial epilepsy. These lesions are being increasingly identified by high quality images provided by magnetic resonance imaging (MRI), resulting in improved seizure control of surgically treated patients. Small dysplastic lesions are often missed by conventional MRI methods. The identification of subtle structural abnormalities by rectilinear slices is often limited by the complex convolutional pattern of the brain. We developed a method of curvilinear reformatting of three-dimensional MRI data that improves the anatomical display of the gyral structure of the hemispheric convexities. It also reduces the asymmetric sampling of gray-white matter that may lead to false-positive results. We present 5 patients in whom conventional two-dimensional and three-dimensional MRI with multiplanar reformatting was initially considered normal. Subsequent studies using curvilinear reformatting identified lesions in all. Four patients underwent surgery with histological diagnosis of focal cortical dysplasia. Three patients are seizure-free and 1 had significant improvement in seizure control. These results indicate that an increase in the detection of subtle focal dysplastic lesions may be accomplished when one improves the anatomical display of the brain gyral structure by performing curvilinear reformatting.
- Publication
Annals of Neurology, 1999, Vol 46, Issue 1, p88
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/1531-8249(199907)46:1<88::AID-ANA13>3.0.CO;2-4