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- Title
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
- Authors
Kaniwa, Nahoko; Saito, Yoshiro; Aihara, Michiko; Matsunaga, Kayoko; Tohkin, Masahiro; Kurose, Kouichi; Furuya, Hirokazu; Takahashi, Yukitoshi; Muramatsu, Masaaki; Kinoshita, Shigeru; Abe, Masamichi; Ikeda, Hiroko; Kashiwagi, Mariko; Yixuan Song; Ueta, Mayumi; Chie Sotozono; Zenro Ikezawa; Hasegawa, Ryuichi
- Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine-induced SJS/TEN in Japanese.
- Subjects
HLA histocompatibility antigens; STEVENS-Johnson Syndrome; TOXIC epidermal necrolysis; GENOTYPE-environment interaction; PATIENTS
- Publication
Epilepsia (Series 4), 2010, Vol 51, Issue 12, p2461
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/j.1528-1167.2010.02766.x