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- Title
Clinical Implications of Micrometastasis Detection in Internal Mammary Nodes of Breast Cancer Patients.
- Authors
Zeng, Jian; Xie, Huazhi; Lu, Yunfei; Feng, Zhenbo; Li, Fu
- Abstract
Background: The aim of this study was to assess the efficiency of step-serial sectioning (SSS) combined with hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining in detecting micrometastasis of internal mammary lymph nodes (IMLNs). Patients and Methods: 135 IMLNs from 88 breast cancer patients were re-examined by SSS, combined with either H&E or IHC staining of the biomarkers cytokeratin-19 and epithelial membrane antigen. Results: Of the 135 IMLNs, 6 nodes from 5 cases displayed 1 or more micrometastases. Histological grade and lymphovascular invasion status were significantly correlated with micrometastasis in the IMLNs (p = 0.018 and 0.001, respectively). Of the 6 nodes positive for micrometastasis, 1 node was detected by both H&E and IHC staining. The remaining 5 nodes from 4 cases showed evident tumor cells only by IHC staining. Finally 8 of the 83 patients (9.64%) without IMLN metastasis showed distant metastasis, while 2 of the 5 patients (40%) with IMLN metastasis showed distant metastasis within 28 months of operation. Conclusion: SSS combined with H&E and IHC staining is more efficient in detecting micrometastasis than classic routine single-slice H&E only. Copyright © 2012 S. Karger AG, Basel
- Subjects
BREAST tumor diagnosis; DIAGNOSTIC imaging; METASTASIS; BREAST tumors; STAINS &; staining (Microscopy); WOMEN'S health; DISEASE complications; DIAGNOSIS
- Publication
Breast Care, 2012, Vol 7, Issue 3, p216
- ISSN
1661-3791
- Publication type
Journal Article
- DOI
10.1159/000339686