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- Title
Protective Effects of Interleukin-37 Expression against Acetaminophen-Induced Hepatotoxicity in Mice.
- Authors
Xu, Zhiwei; Li, Kan; Pan, Xiuhe; Tan, Jun; Li, Yan; Li, Mingcai
- Abstract
Aim. Interleukin (IL)-37 is a new anti-inflammatory cytokine of the IL-1 family. This study aimed to determine the effects of IL-37 on acetaminophen (APAP)-induced liver injury. Materials and Methods. IL-37 plasmids were injected into mice via a tail vein hydrodynamics-based gene delivery. Results. Our results showed that IL-37 pretreatment significantly decreased serum alanine aminotransferase and aspartate aminotransferase levels, hepatic myeloperoxidase activity, and attenuated the histological liver damage. Compared to the APAP group, IL-37 administration decreased Kupffer cells numbers in the liver of APAP-induced hepatotoxicity in mice. Furthermore, IL-37 pretreatment reduced the expression of proinflammatory cytokines including tumor necrosis factor-α, IL-6, IL-17, and nuclear factor-κB (NF-κB) in APAP-induced mice. Conclusion. These results demonstrate that delivery of IL-37 plasmid can ameliorate APAP-induced liver injury by reducing proinflammatory cytokines production and preventing the activation of the NF-κB signaling pathway. IL-37 may be a promising candidate against APAP-induced liver injury.
- Subjects
LIVER injuries; INTERLEUKINS; CYTOKINES; ACETAMINOPHEN; ANIMAL experimentation; PLASMIDS; HEPATOTOXICOLOGY; MICE; ALANINE aminotransferase; ASPARTATE aminotransferase
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2022, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2022/6468299