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- Title
The Influence of Melatonin on Brain Tumors: A Comprehensive Review.
- Authors
DURANKUŞ, Nülifer KILIÇ; BECKER, Aline Paixão; BECKER, Valesio; SELEK, Uğur
- Abstract
Primary brain tumors are a heterogeneous group of neoplasms, originating from glial and other cell types in the central nervous system (CNS). Despite advancements in technology and medicine, the prognosis for malignant brain tumors remains poor. This situation requires novel therapeutic approaches. Melatonin, a hormone produced by the pineal gland, regulates sleep and circadian rhythms. It also possesses various biological functions, such as antioxidant properties, immune modulation, and tumor suppression. This review analyzes existing research on the effects of melatonin on brain tumors, focusing on its therapeutic potential and mechanisms of action, and highlights melatonin’s promise as a complementary therapy against adult and pediatric high-grade gliomas.
- Subjects
THERAPEUTIC use of antioxidants; GLIOMAS; HORMONES; PINEAL gland; MELATONIN; IMMUNE system; MOLECULAR structure; ALTERNATIVE medicine; SLEEP; CIRCADIAN rhythms; BRAIN tumors; CHILDREN; ADULTS
- Publication
Turkish Journal of Oncology / Türk Onkoloji Dergisi, 2024, Vol 39, Issue 3, p325
- ISSN
1300-7467
- Publication type
Article
- DOI
10.5505/tjo.2024.4387