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- Title
Shorter EGFR Dinucleotide Repeat Length Predicts Better Response of Patients with Advanced Non-small Cell Lung Cancer to EGFR Tyrosine Kinase Inhibitor.
- Authors
Chen, Bin; Luo, Jie; Gu, Weiqing; Shen, Li; Wang, Heyong; Zhou, Songwen
- Abstract
The purpose of this study is to evaluate the association between intron 1 CA-repeat polymorphisms of the epidermal growth factor receptor gene ( EGFR) and the clinical outcome of Chinese patients with advanced non-small cell lung cancer (NSCLC) treated with EGFR tyrosine kinase inhibitors (TKIs). We genotyped the intron 1 CA-repeat genetic polymorphisms of EGFR in 84 Chinese patients with NSCLC. The relationship between the length of the CA repeats and EGFR mutations in exons 18-21 in the 84 patients was elucidated. We then analyzed the association between the length of the CA repeats and the clinical outcome of EGFR-TKI-treated patients with NSCLC. EGFR mutations in exon 19 were significantly associated with shorter CA repeats. Patients with shorter CA repeats had a significantly longer progression-free survival with EGFR-TKI treatment than those with longer CA repeats. Our results suggest that shorter CA repeats in intron 1 of EGFR are associated with EGFR mutations and the clinical outcomes of TKI-treated patients with NSCLC.
- Subjects
CANCER treatment; NON-small-cell lung carcinoma; EPIDERMAL growth factor receptors; DINUCLEOTIDES; PROTEIN-tyrosine kinase inhibitors; REPEATED sequence (Genetics); GENETIC mutation; GENETIC polymorphisms; PROGRESSION-free survival
- Publication
Cell Biochemistry & Biophysics, 2015, Vol 73, Issue 3, p799
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-014-0289-6