We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Characteristics of extracellular cyclic AMP-dependent protein kinase as a biomarker of cancer in dogs.
- Authors
Bhang, D. H.; Choi, U. S.; Kim, B. G.; Lee, S.‐N.; Lee, S.; Roh, H.‐S.; Chung, W.‐J.; Jeon, K. O.; Song, W. J.; Youn, H.‐Y.; Baek, K.‐H.
- Abstract
Objective Early and proper diagnosis of cancer is the most critical factor for the survival and treatment of veterinary cancer patients. In this study, we evaluated extracellular cyclic AMP-dependent protein kinase A ( ECPKA) level in serum as a useful cancer biomarker in dogs. Methods ECPKA levels were detected in sera from dogs with cancers ( n = 48), benign tumours ( n = 18), and non-tumour diseases ( n = 102) as well as healthy control dogs ( n = 54) utilizing enzyme-linked immunosorbent assay ( ELISA). Results Sera from dogs bearing various types of cancer exhibited markedly increased levels of ECPKA by up to 7.1-, 8.8-, and 10.9-fold compared with those from dogs harbouring benign tumours, dogs with non-tumour diseases, and healthy control dogs, respectively ( P < .0001). In addition, serum ECPKA level did not show statistically significant correlation with gender, breed, or age of dogs or their non-cancerous disease conditions. Conclusion Our data strongly propose that detection of serum ECPKA level is a potential and specific diagnostic tool for cancer in dogs.
- Subjects
ENZYME-linked immunosorbent assay; CANCER in dogs; EXTRACELLULAR matrix; CYCLIC-AMP-dependent protein kinase; SERUM
- Publication
Veterinary & Comparative Oncology, 2017, Vol 15, Issue 4, p1585
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12304