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- Title
Treatment of vascular and soft-tissue sarcomas in dogs using an alternating protocol of ifosfamide and doxorubicin.
- Authors
Payne, S. E.; Rassnick, K. M.; Northrup, N. C.; Kristal, O.; Chretin, J. D.; Cotter, S. M.; Kintzer, P.; Frimberger, A. E.; Morrison-Collister, K. E.; Wood, C. A.; Moore, A. S.
- Abstract
A retrospective analysis was done to assess the toxicity and efficacy associated with an alternating chemotherapy protocol of ifosfamide (375 mg m−2) and doxorubicin (30 mg m−2) for adjuvant treatment of 39 dogs with sarcomas. Twelve dogs had various soft-tissue sarcomas and 27 dogs had hemangiosarcoma (HSA). Complete blood counts were evaluated 7 days after the first dose of ifosfamide and doxorubicin. One dog had grade 4 neutropenia (<500 µL−1) after treatment with ifosfamide and one dog had grade 3 neutropenia (500–1000 µL−1) after treatment with doxorubicin. One dog treated with doxorubicin was hospitalized for 24 h due to vomiting. The median survival time (ST) for the 27 dogs with HSA treated by surgery and with doxorubicin/ifosfamide was 149 days (mean 366 days). Although the protocol of alternating ifosfamide and doxorubicin was well tolerated, it failed to result in a statistically significant improvement in the ST when compared to a historical population of dogs with stage 2 splenic HSA treated by surgery alone.
- Subjects
SARCOMA; CANCER treatment; SOFT tissue tumors; DOXORUBICIN; DRUG therapy; NEUTROPENIA; ANGIOSARCOMA
- Publication
Veterinary & Comparative Oncology, 2003, Vol 1, Issue 4, p171
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5810.2003.00024.x