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- Title
Sensitive Voltammetric Determination of Baicalein at Thermally Reduced Graphene Oxide Modified Glassy Carbon Electrode.
- Authors
Zhang, Dongdong; Zhang, Yanmin; He, Langchong
- Abstract
This work presents a sensitive voltammetric method for determination of the flavonoid baicalein by using a thermally reduced graphene oxide (TRGO) modified glassy carbon electrode (GCE) in 100 mM KCl-10 mM sodium phosphate buffer solution (pH 7.40). The surface morphology and structure of TRGO investigated by atomic force microscopy, FT-IR spectroscopy and Raman spectroscopy reveal that the TRGO prepared maintained as single or bilayer sheets and with significant edge-plane-like defect sites. The TRGO/GCE modified electrode shows more favorable electron transfer kinetics for potassium ferricyanide and potassium ferrocyanide probe molecules, which are important electroactive compounds, compared with bare GCE and GO/GCE electrodes. The electrochemical behaviors of baicalein at the TRGO/GCE were investigated by cyclic voltammetry, suggesting that the TRGO/GCE exhibits excellent electrocatalytic activity to baicalein. Under physiological conditions, the modified electrode showed linear voltammetric response from 10 nM to 10 µM for baicalein, with a detection limit of 6.0 nM. This work demonstrates that the graphene-modified electrode is a promising tool for electrochemical determination of flavonoid drugs.
- Subjects
GRAPHENE oxide; CARBON electrodes; FLAVONOIDS; SODIUM phosphates; CHARGE exchange; ATOMIC force microscopy; RAMAN spectroscopy
- Publication
Electroanalysis, 2013, Vol 25, Issue 9, p2136
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201300189