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- Title
High‐Performance Quinoline‐Malononitrile Core as a Building Block for the Diversity‐Oriented Synthesis of AIEgens.
- Authors
Guo, Zhiqian; Yan, Chenxu; Zhu, Wei‐Hong
- Abstract
In vivo fluorescent monitoring of physiological processes with high‐fidelity is essential in disease diagnosis and biological research, but faces extreme challenges due to aggregation‐caused quenching (ACQ) and short‐wavelength fluorescence. The development of high‐performance and long‐wavelength aggregation‐induced emission (AIE) fluorophores is in high demand for precise optical bioimaging. The chromophore quinoline‐malononitrile (QM) has recently emerged as a new class of AIE building block that possesses several notable features, such as red to near‐infrared (NIR) emission, high brightness, marked photostability, and good biocompatibility. In this minireview, we summarize some recent advances of our established AIE building block of QM, focusing on the AIE mechanism, regulation of emission wavelength and morphology, the facile scale‐up and fast preparation for AIE nanoparticles, as well as potential biomedical imaging applications.
- Subjects
PATIENT monitoring; NANOPARTICLES; DIAGNOSIS; BIOLOGICAL research; FLUORESCENCE
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 25, p9896
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201913249