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- Title
Low‐Fouling Fluoropolymers for Bioconjugation and In Vivo Tracking.
- Authors
Fu, Changkui; Demir, Baris; Alcantara, Sheilajen; Kumar, Vinod; Han, Felicity; Kelly, Hannah G.; Tan, Xiao; Yu, Ye; Xu, Weizhi; Zhao, Jiacheng; Zhang, Cheng; Peng, Hui; Boyer, Cyrille; Woodruff, Trent M.; Kent, Stephen J.; Searles, Debra J.; Whittaker, Andrew K.
- Abstract
The conjugation of hydrophilic low‐fouling polymers to therapeutic molecules and particles is an effective approach to improving their aqueous stability, solubility, and pharmacokinetics. Recent concerns over the immunogenicity of poly(ethylene glycol) has highlighted the importance of identifying alternative low fouling polymers. Now, a new class of synthetic water‐soluble homo‐fluoropolymers are reported with a sulfoxide side‐chain structure. The incorporation of fluorine enables direct imaging of the homopolymer by 19F MRI, negating the need for additional synthetic steps to attach an imaging moiety. These self‐reporting fluoropolymers show outstanding imaging sensitivity and remarkable hydrophilicity, and as such are a new class of low‐fouling polymer for bioconjugation and in vivo tracking.
- Subjects
FLUOROPOLYMERS; ETHYLENE glycol; POLYMERS; SOLUBILITY
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 12, p4759
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201914119