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- Title
Iron‐Catalyzed Direct Oxidative Alkylation and Hydroxylation of Indolin‐2‐ones with Alkyl‐Substituted N‐Heteroarenes.
- Authors
Hu, Ren‐Ming; Han, Dong‐Yang; Li, Ning; Huang, Jie; Feng, Yu; Xu, Da‐Zhen
- Abstract
Presented herein is the first direct alkylation and hydroxylation reaction between two different C(sp3)−H bonds, indolin‐2‐ones and alkyl‐substituted N‐heteroarenes, through an oxidative cross‐coupling reaction. The reaction is catalyzed by a simple iron salt under mild ligand‐free and base‐free conditions. The reaction is environmentally benign, employs air (molecular oxygen) as the terminal oxidant and oxygen source for the synthesis of O‐containing compounds, and produces only water as the byproduct.
- Subjects
ALKYLATION; HYDROXYLATION; OXYGEN; OXIDATION; SALT; COUPLING reactions (Chemistry); OXIDIZING agents
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 10, p3904
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201913400