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- Title
Ruthenium(II)‐Catalyzed C−H Difluoromethylation of Ketoximes: Tuning the Regioselectivity from the <italic>meta</italic> to the <italic>para</italic> Position.
- Authors
Yuan, Chunchen; Zeng, Runsheng; Zhao, Yingsheng; Zhu, Lei; Lan, Yu
- Abstract
Abstract: A highly <italic>para</italic>‐selective CAr−H difluoromethylation of ketoxime ethers under ruthenium catalysis has been developed. A wide variety of ketoxime ethers are compatible with the reaction, which leads to the corresponding <italic>para</italic>‐difluoromethylated products in moderate to good yield. A mechanistic study clearly showed that chelation‐assisted cycloruthenation is the key factor in the <italic>para</italic> selectivity of the difluoromethylation of ketoxime ethers. Density functional theory was used to gain a theoretical understanding of the <italic>para</italic> selectivity.#
- Subjects
CARBON-hydrogen bonds; METHYLATION; OXIME derivatives; RUTHENIUM catalysts; REGIOSELECTIVITY (Chemistry); CHELATION; DENSITY functional theory
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 5, p1291
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201711221