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- Title
Tuning the Inter-nanofibril Interaction To Regulate the Morphology and Function of Peptide/DNA Co-assembled Viral Mimics.
- Authors
Ni, Rong; Chau, Ying
- Abstract
The ability to tune the inter-subunit interaction within the virus capsid may be critical to assembly and biological function. This process was extended here with peptide/DNA co-assembled viral mimics. The resulting co-assemblies, formed and stabilized by both peptide nanofibril–DNA and peptide nanofibril–nanofibril interactions, were tuned through hydrophobic packing interactions of the peptide sequences. By strengthening peptide side-chain complementarity and/or elongating the peptide chain (from 4 to 8 residues), we report strengthening the inter-nanofibril interaction to create stable nanococoons that give high gene-transfection efficacy.
- Subjects
CAPSIDS; MIMICRY (Biology); PEPTIDES; DNA; VIRUSES
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 32, p9484
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201703596