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- Title
Total Synthesis of the Post-translationally Modified Polyazole Peptide Antibiotic Goadsporin.
- Authors
Dexter, Hannah L.; Williams, Huw E. L.; Lewis, William; Moody, Christopher J.
- Abstract
The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues. An efficient total synthesis of goadsporin is reported in which the key steps are the use of rhodium(II)-catalyzed reactions of diazocarbonyl compounds to generate the four oxazole rings, which demonstrates the power of rhodium carbene chemistry in organic chemical synthesis.
- Subjects
ANTIBIOTIC synthesis; OXAZOLES; THIAZOLES; AMINO acids; RHODIUM catalysts; RHODIUM carbenes
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 11, p3115
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201612103