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- Title
Highly Stereoselective Gold-Catalyzed Coupling of Diazo Reagents and Fluorinated Enol Silyl Ethers to Tetrasubstituted Alkenes.
- Authors
Liao, Fu ‐ Min; Cao, Zhong ‐ Yan; Yu, Jin ‐ Sheng; Zhou, Jian
- Abstract
We report a highly stereoselective synthesis of all-carbon or fluorinated tetrasubstituted alkenes from diazo reagents and fluorinated enol silyl ethers, using C−F bond as a synthetic handle. Cationic AuI catalysis plays a key role in this reaction. Remarkable fluorine effects on the reactivity and selectivity was also observed.
- Subjects
STEREOSELECTIVE reactions; GOLD; CATALYSIS; DIAZO compounds; COUPLING agents (Chemistry); FLUORINATION; SILYL enol ethers; ALKENES
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 9, p2499
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201611625