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- Title
Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized α-Ketoamides.
- Authors
Nagaki, Aiichiro; Takahashi, Yusuke; Yoshida, Jun‐ichi
- Abstract
Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α-ketoamides. The present method could be applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent.
- Subjects
CARBAMOYL compounds; ORGANOLITHIUM compounds; AMIDE derivatives; FLUID flow; KETONE derivatives; TRIAZINE derivatives; METHYL formate; MICROREACTORS
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 17, p5413
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201601386