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- Title
Enantioselective Palladium-Catalyzed CH Functionalization of Indoles Using an Axially Chiral 2,2′-Bipyridine Ligand.
- Authors
Gao, Xiang; Wu, Bo; Huang, Wen ‐ Xue; Chen, Mu ‐ Wang; Zhou, Yong ‐ Gui
- Abstract
A palladium-catalyzed enantioselective CH functionalization of indoles was achieved with an axially chiral 2,2′-bipyridine ligand, thus providing the desired indol-3-acetate derivatives with up to 98 % ee. Moreover, the reaction protocol was also effective for asymmetric OH insertion reaction of phenols using α-aryl-α-diazoacetates. This represents the first successful application of bipyridine ligands with axial chirality in palladium-catalyzed carbene migratory insertion reactions.
- Subjects
ENANTIOSELECTIVE catalysis; PALLADIUM catalysts; CARBON-hydrogen bonds; INDOLE compounds; BIPYRIDINE; INSERTION reactions (Chemistry)
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 41, p12124
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504483