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- Title
Final-Stage Site-Selective Acylation for the Total Syntheses of Multifidosides A-C.
- Authors
Ueda, Yoshihiro; Furuta, Takumi; Kawabata, Takeo
- Abstract
The first total syntheses of multifidosides A-C have been achieved. The synthetic strategy is characterized by catalytic site-selective acylation of unprotected glycoside precursors in the final stage of the synthesis. High functional-group tolerance of the site-selective acylation, promoted by an organocatalyst, enabled the conventionally difficult molecular transformation in a predictable and reliable manner. An advantage of this strategy is to avoid the risks of undesired side reactions during the removal of the protecting groups at the final stage of the total synthesis.
- Subjects
ACYLATION; CHEMICAL synthesis; GLYCOSIDES; CHEMICAL amplification; PTERIS
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 41, p12134
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504729