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- Title
Total Synthesis of (±)-Hippolachnin A.
- Authors
Ruider, Stefan A.; Sandmeier, Tobias; Carreira, Erick M.
- Abstract
The first total synthesis of the marine polyketide (±)-hippolachnin A has been achieved in nine linear steps and an overall yield of 9 %. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.
- Subjects
CHEMICAL synthesis; POLYKETIDES; RING formation (Chemistry); ENE reactions; PERICYCLIC reactions
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 8, p2408
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201410419