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- Title
A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins.
- Authors
Qu, Bo; Samankumara, Lalith P.; Ma, Shengli; Fandrick, Keith R.; Desrosiers, Jean ‐ Nicolas; Rodriguez, Sonia; Li, Zhibin; Haddad, Nizar; Han, Zhengxu S.; McKellop, Keith; Pennino, Scott; Grinberg, Nelu; Gonnella, Nina C.; Song, Jinhua J.; Senanayake, Chris H.
- Abstract
Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-dihydronaphthalenes under one atmosphere pressure of H2, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1-tetralones.
- Subjects
OXAZOLINE; IRIDIUM catalysts; HYDROGENATION; HYDROCARBONS; CHIRALITY; IMINE derivatives; TETRALONES
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 52, p14656
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201408929