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- Title
In prenatally diagnosed CPAM, does the affected lobe influence the timing of symptom onset?
- Authors
Sueyoshi, R.; Shibuya, S.; Ochi, T.; Okawada, M.; Miyano, G.; Koga, H.; Lane, G. J.; Yamataka, A.
- Abstract
<bold>Purpose: </bold>We investigated the relationship between the affected lobe and symptom onset in prenatally diagnosed congenital pulmonary airway malformation (CPAM).<bold>Methods: </bold>53 CPAM patients diagnosed prenatally were reviewed retrospectively by creating 2 groups according to symptom onset. Group Sneo: (symptomatic during the neonatal period; n = 13) and group S > neo: (symptomatic after the neonatal period; n = 40) were compared for type of CPAM, affected lobes, types of symptoms/infections, treatment, duration of follow-up, and histopathology. Requirement for surgery (Sx) was then used to create three subgroups: Sneo + Sx, S > neo + Sx, and Sx-.<bold>Results: </bold>Some cases had multiple affected lobes. In Sneo, symptoms developed in 55.6%, 50.0%, 0%, 0%, and 36.8% of right upper lobes (RUL), right middle lobes (RML), right lower lobes (RLL), left upper lobes (LUL), and left lower lobes (LLL) diagnosed with CPAM, prenatally. In S > neo, symptoms developed in 0%, 0%, 6.3%, 55.6%, and 33.3% of RUL, RML, RLL, LUL, and LLL diagnosed with CPAM, prenatally.<bold>Conclusion: </bold>In prenatally diagnosed CPAM, RUL and RML lesions are more likely to become symptomatic in neonates, and LUL lesions in infants. Surgery is recommended before the onset of respiratory infections after 1 year of age.
- Subjects
RESPIRATORY infections; NEONATAL infections; LUNG infections; NATURAL history; NEWBORN infants
- Publication
Pediatric Surgery International, 2019, Vol 35, Issue 5, p559
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-019-04460-x