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- Title
Effect of microbubble-enhanced ultrasound on percutaneous ethanol ablation of rat walker-256 tumour.
- Authors
Gao, Wenhong; Qiao, Lu; Gao, Yuejuan; Zhang, Li; Zhang, Dong; Tu, Juan; Liu, Zheng; Xie, Feng
- Abstract
<bold>Objectives: </bold>Percutaneous ethanol ablation (PEA) is an effective method for treating small liver cancer. Microbubble-enhanced ultrasound (MEUS) can potentially promote PEA by disrupting the tumour's circulation. In this study, treatment combining MEUS and PEA was performed to find any synergistic effects in tumour ablation.<bold>Methods: </bold>Ten rats bearing subcutaneous Walker-256 tumours were treated by MEUS combined with PEA. The other 18 tumour-bearing rats that were treated by MEUS or PEA served as the controls. MEUS was conducted by therapeutic ultrasound (TUS) and microbubble injection. TUS was operated at a frequency of 831 KHz with a pressure amplitude of 4.3 MPa. Tumour blood perfusion was assessed by contrast-enhanced ultrasound (CEUS), and the tumour necrosis rate was determined by histological examination.<bold>Results: </bold>CEUS showed that the tumour blood perfusion almost vanished in all of the MEUS-treated tumours. The contrast peak intensity dropped 84.8 % in the MEUS + PEA-treated tumours when compared to 46.3 % (p < 0.05) in the PEA-treated tumours 24 h after treatment. The tumour necrosis rate of the combination therapy was 97.50 %, which is much higher than that of the MEUS- (66.2 %) and PEA-treated (81.0 %) tumours.<bold>Conclusion: </bold>PEA combined with MEUS can induce a much more complete tumour necrosis.<bold>Key Points: </bold>• This experiment demonstrated a novel method for enhancing percutaneous ethanol ablation. • Microbubble-enhanced therapeutic ultrasound is capable of disrupting tumour circulation. • Combined therapy of MEUS and PEA can induce more complete necrosis of tumours.
- Subjects
ABLATION techniques; LIVER cancer; MICROBUBBLE diagnosis; TUMORS; TUMOR necrosis factors; CANCER treatment; SARCOMA; NONIONIZING radiation; ANIMAL experimentation; CELL lines; COMBINED modality therapy; DIAGNOSTIC imaging; ETHANOL; SCLEROTHERAPY; RATS; EQUIPMENT &; supplies; CONTRAST media; THERAPEUTICS
- Publication
European Radiology, 2016, Vol 26, Issue 9, p3017
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-4153-x