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- Title
Interscan variation of semi-automated volumetry of subsolid pulmonary nodules.
- Authors
Scholten, Ernst; Jong, Pim; Jacobs, Colin; Ginneken, Bram; Riel, Sarah; Willemink, Martin; Vliegenthart, Rozemarijn; Oudkerk, Matthijs; Koning, Harry; Horeweg, Nanda; Prokop, Mathias; Mali, Willem; Gietema, Hester; Scholten, Ernst Th; de Jong, Pim A; van Ginneken, Bram; van Riel, Sarah; Willemink, Martin J; de Koning, Harry J; Mali, Willem P Th M
- Abstract
<bold>Rationale: </bold>We aimed to test the interscan variation of semi-automatic volumetry of subsolid nodules (SSNs), as growth evaluation is important for SSN management.<bold>Methods: </bold>From a lung cancer screening trial all SSNs that were stable over at least 3 months were included (N = 44). SSNs were quantified on the baseline CT by two observers using semi-automatic volumetry software for effective diameter, volume, and mass. One observer also measured the SSNs on the second CT 3 months later. Interscan variation was evaluated using Bland-Altman plots. Observer agreement was calculated as intraclass correlation coefficient (ICC). Data are presented as mean (± standard deviation) or median and interquartile range (IQR). A Mann-Whitney U test was used for the analysis of the influence of adjustments on the measurements.<bold>Results: </bold>Semi-automatic measurements were feasible in all 44 SSNs. The interscan limits of agreement ranged from -12.0 % to 9.7 % for diameter, -35.4 % to 28.6 % for volume and -27.6 % to 30.8 % for mass. Agreement between observers was good with intraclass correlation coefficients of 0.978, 0.957, and 0.968 for diameter, volume, and mass, respectively.<bold>Conclusion: </bold>Our data suggest that when using our software an increase in mass of 30 % can be regarded as significant growth.<bold>Key Points: </bold>• Recently, recommendations regarding subsolid nodules have stressed the importance of growth quantification. • Volumetric measurement of subsolid nodules is feasible with good interscan agreement. • Increase of mass of 30 % can be regarded as significant growth.
- Subjects
LUNG cancer; CANCER diagnosis; TOMOGRAPHY; CANCER genetics; CARCINOGENESIS; COMPUTED tomography; LUNG tumors; RESEARCH bias; EARLY detection of cancer; SOLITARY pulmonary nodule
- Publication
European Radiology, 2015, Vol 25, Issue 4, p1040
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-014-3478-1