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- Title
Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery.
- Authors
Won Joon Seong; Douk Hun Yoon; Gun Oh Chong; Dae Gy Hong; Tae Bon Koo; Taek Hoo Lee; Sang Sik Chun
- Abstract
To evaluate cord blood amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels according to the mode of delivery. Between 1 March and 31 May 2007, 106 blood samples were drawn from the umbilical vein at the time of delivery. Eighty-four NT-proBNP levels [63 term (34 cesarean sections and 29 vaginal deliveries) and 21 preterm births] were analyzed with respect to gestational age, birth weight, Apgar score, newborn gender, and cord blood pH. There was no statistical significance on comparison of the mean NT-proBNP values between the cesarean and vaginal delivery groups (801.9 ± 537.7 vs. 724.3 ± 542.4 pg/ml, respectively; P = 0.572). The correlation of NT-proBNP with gestational age, birth weight, and cord blood pH was −0.616, −0.585, and −0.202, respectively. The mean values for NT-proBNP levels were compared according to the newborn gender (male vs. female; P = 0.926), and Apgar score at 1 min [>6 ( N = 71) vs. ≤6 ( N = 13); P = 0.001]. Vaginal delivery did not result in increased cord blood NT-proBNP levels reflecting cardiovascular stress to the fetal heart. NT-proBNP was inversely correlated with gestational age. Low Apgar score and umbilical cord blood pH appeared to induce the fetus to produce increased amounts of NT-proBNP.
- Subjects
CORD blood; ATRIAL natriuretic peptides; DELIVERY (Obstetrics); NEWBORN screening; BIRTH weight; CESAREAN section
- Publication
Archives of Gynecology & Obstetrics, 2010, Vol 281, Issue 5, p907
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-009-1253-3