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- Title
The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis.
- Authors
Jinfeng Liu; Yongqin Li; Tianyan Chen; Yuan Yang; Ke Wang; Yingli He; Qian Yang; Feng Ye; Yan Jin; Ting Qiu; Shumei Lin; Min Liu; Yingren Zhao
- Abstract
Using a nested-PCR genotyping system, we analyzed the viral genotypes in HBV-infected patients from HBV clustering infection families (CIFs), as compared with HBV infected patients without familial infection history. The patients in the CIF group showed significantly increased prevalence of genotype C infection, while genotype B was absent. Additionally, in the genotype C carriers younger than 50 years old, the prevalence of HCC and LC were significantly increased in CIF compared to the control. We found that HBeAg-positive HBV genotype C carriers are prone to develop end-stage liver diseases earlier than those infected by genotype B.
- Subjects
PROGNOSIS; DIAGNOSIS; GENETIC polymorphisms; GENETIC research; BILIARY tract
- Publication
Archives of Virology, 2008, Vol 153, Issue 11, p2157
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-008-0239-y