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- Title
Epithelial-to-mesenchymal transition of the mesothelial cell—its role in the response of the peritoneum to dialysis.
- Authors
Selgas, Rafael; Bajo, Auxiliadora; Jiménez-Heffernan, José A.; Sánchez-Tomero, Jose A.; del Peso, Gloria; Aguilera, Abelardo; López-Cabrera, Manuel
- Abstract
Peritoneal membrane fibrosis, ranging from mild inflammation to severe sclerosing peritonitis, is one of the complications of peritoneal dialysis (PD). In parallel with fibrosis, the peritoneum shows a progressive increase of capillaries and vasculopathy, involved in increased small solute transport across the membrane and ultrafiltration failure. Glucose and glucose degradation products from PD solutions are responsible of stimulating transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) production by mesothelial cells (MCs). TGF-β is a potent pro-fibrotic factor and inducer of epithelial-to-mesenchymal transition (EMT) of the MC. Local production of VEGF by transitional MC appears to play a central role in the processes leading to peritoneal angiogenesis.
- Publication
Nephrology Dialysis Transplantation, 2006, Vol 21, pii2
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfl183