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- Title
Evaluation of temafloxacin in a rat model of intra-abdominal abscess.
- Authors
Thadepalli, Haragopal; Hajji, Mayy; Perumal, Veluchamy K.; Chuan, See-Kean; Gollapudi, Sastry; Thadepalli, H; Hajji, M; Perumal, V K; Chuah, S K; Gollapudi, S
- Abstract
The in-vitro activity of temafloxacin, a new fluoroquinolone, was evaluated in an experimental model of intra-abdominal abscess in rats. Mixed aerobic-anaerobic infection was induced by intraperitoneal implantation of gelatin capsules containing Bacteroides fragilis, Escherichia coli, and sterile rat faeces. Temafloxacin was highly active with a 90.9% cure rate in comparison with no treatment (no cures; P less than 0.0001), and as active as a combination of clindamycin and gentamicin (100% cure rate; P greater than 0.05). Temafloxacin (12 mg/dose) gave rise to serum concentrations that exceeded the MIC values of both microorganisms for at least 8 h.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1992, Vol 29, Issue 6, p687
- ISSN
0305-7453
- Publication type
journal article