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- Title
Diffusion of ceftriaxone into the cerebrospinal fluid of adults.
- Authors
Chandrasekar, Pranatharthi H.; Rolston, Kenneth V. I.; Smith, Bruce R.; LeFrock, Jack L.; Chandrasekar, P H; Rolston, K V; Smith, B R; LeFrock, J L
- Abstract
Fourteen adults, three recovering from bacterial meningitis, were given a single 2 g dose of ceftriaxone or three 2 g doses at 12-hourly intervals. The mean per cent penetration of drug into cerebrospinal fluid (CSF) across uninflamed meninges was 1.5%. These levels, although low, are bactericidal in vitro against most pathogens causing meningitis.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1984, Vol 14, Issue 4, p427
- ISSN
0305-7453
- Publication type
journal article