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- Title
Pharmacokinetics and tolerance of a 24-h infusion of cefotetan disodium (with and without loading dose) in normal Caucasian volunteers.
- Authors
Adam, H. K.; Houghton, H. L.; Yates, R. A.; Young, J.; Donnelly, R. J.
- Abstract
Cefotetan disodium has been given by zero order intravenous infusion at 75.8 mg/h to four healthy male volunteers over a 24-h period. Plasma concentrations rose until by 12 hs a mean steady state value of 37.5 mg/l was attained. In an additional four volunteers a loading dose of 0.5 g cefotetan was given immediately prior to a similar infusion. In these subjects concentrations in excess of the final steady-state value of 36.2 mg/l were achieved immediately and concentrations never fell below this value for the entire 24-h period of the study. The dose was well tolerated with the exception of an incidence of diarrhoea (2/8 mild and 1/8 severe). The pharmacokinetic findings are in good agreement with theoretical predictions based on single intravenous bolus doses of cefotetan and suggest that a loading dose, followed by an infusion would be suitable regime for cases of severe infection.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1983, Vol 11, Issue suppl_A, p193
- ISSN
0305-7453
- Publication type
journal article