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- Title
Cytogenetic Anomalies in Multiple Myeloma Patients: A Single Center Study.
- Authors
Bozkurt, Süreyya; Büyükaşık, Yahya; Demiroğlu, Haluk; Karakulak, Elifcan Aladağ; Okay, Müfide; Karataş, Ayşe; Aksu, Salih; Haznedaroğlu, İbrahim C.; Sayınalp, Nilgün; Özcebe, Osman I.; Göker, Hakan
- Abstract
Conventional karyotyping in the patients with Multiple myeloma (MM) is very important because the detected chromosomal abnormalities have diagnostic and prognostic value. In this retrospective study we aim to evaluate cytogenetic abnormalities in 133 MM patients whose diagnosis was established at the Hematology Department of Hacettepe University. The bone marrow samples were treated with trypsin and stained with Giemsa (GTG banding). For each patient, 20 metaphases were examined and karyotypes were formed. Cytogenetic results of the patient's bone marrow samples were obtained in 114 patients. Of 114 examined karyotypes, 80 patients had normal karyotype while 34 patients had abnormal karyotypes. Both numerical and structural chromosomal anomalies were detected in patients with abnormal karyotype. The most frequent numerical and structural anomalies were detected in chromosomes 1, 9, 16 and 13. The anomalies we found in our patient group were consistent with the literature.
- Subjects
MULTIPLE myeloma; BONE marrow; KARYOTYPES; ACADEMIC departments
- Publication
Genetics & Applications, 2019, Vol 3, Issue 1, p51
- ISSN
2566-2937
- Publication type
Article
- DOI
10.31383/ga.vol3iss1pp51-56