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- Title
DGARM/C10orf76/ARMH3 for Ceramide Transfer Zone at the Endoplasmic Reticulum–Distal Golgi Contacts.
- Authors
Mizuike, Aya; Hanada, Kentaro
- Abstract
Phosphatidylinositol 4-monophosphate (PtdIns(4)P) is one of the key membrane components which mark the membrane contact sites. In the mammalian Golgi complex, PtdIns(4)P is produced at various subregions via specific mechanisms for each site. Particularly, PtdIns(4)P pools generated at the distal Golgi regions are pivotal for the determination of membrane contacts between the endoplasmic reticulum (ER) and Golgi, at which inter-organelle lipid transport takes place. In this short review, we will focus on C10orf76 (or ARMH3), which we propose to rename as DGARM after a d istal G olgi arm adillo repeat protein, for its function in generating a PtdIns(4)P pool crucial for ER-to-distal Golgi ceramide transport. We further discuss from the viewpoint of the evolutionary conservation of DGARM.
- Subjects
CERAMIDES; GOLGI apparatus; GENERATING functions; LIPID transfer protein; ENDOPLASMIC reticulum
- Publication
Contact (25152564), 2024, p1
- ISSN
2515-2564
- Publication type
Article
- DOI
10.1177/25152564241239443