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- Title
SOX on tumors, a comfort or a constraint?
- Authors
Jiang, Junqing; Wang, Yufei; Sun, Mengyu; Luo, Xiangyuan; Zhang, Zerui; Wang, Yijun; Li, Siwen; Hu, Dian; Zhang, Jiaqian; Wu, Zhangfan; Chen, Xiaoping; Zhang, Bixiang; Xu, Xiao; Wang, Shuai; Xu, Shengjun; Huang, Wenjie; Xia, Limin
- Abstract
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors. This review summarizes the physiological function of the SOX family and their multiple roles in tumors, with a focus on the relationship between the SOX family and TIME, aiming to propose their potential role in cancer and promising methods for treatment.
- Subjects
FORKHEAD transcription factors; EPITHELIAL-mesenchymal transition; DRUG resistance; TUMOR microenvironment; TRANSCRIPTION factors; TUMORS
- Publication
Cell Death Discovery, 2024, Vol 10, Issue 1, pN.PAG
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-024-01834-6