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- Title
Managementul terapiei medicamentoase în Alzheimer, boala secolului XXI.
- Authors
Mitea, Gabriela; Pîndaru, Andreea-Cristina; Bucur, Laura
- Abstract
Alzheimer’s disease is one of the most controversial brain diseases. It is manifested by brains gradual degeneration with age due to the accumulation of proteins but also acetylcholine deficiency, a substance responsible for transmitting messages between brain cells. It was observed that the disease has several risk factors, from genetic transmission to environmental factors and lifestyle of each person. More and more elderly people show symptoms of this disease, and the diagnosis is made late due to the fact that forgetting is considered normal after the average age of 60 years old. Thus, this disease soon becomes the disease of the 21st century, along with other diseases with imminent end. Alzheimer’s disease has several stages in its continuous evolution, stages that can be observed and diagnosed by the doctor through a multitude of tests and the patient’s careful history. The number of people who develop the disease is increasing, and research, although multiple and continuous, is unsuccessful in finding the treatment that can cure patients in different stages of the disease. The specific medication is based on: acetylcholinesterase inhibitors, acetylcholinesterase and butyrylcholinesterase inhibitors, glutamatergic modulators and the combination of cholinesterase inhibitors with a glutamate regulator. A particular importance in the treatment of dementia, along with procognitive therapy, is the therapy on noncognitive disorders, such as depression, psychomotor agitation, psychotic disorders and behavioral changes, achieved by using medication with antipsychotic, antidepressant, thymostabilizing and sedative. Other therapeutic agents are: antioxidants, neurotrophins, statins, nonsteroidal anti-inflammatory drugs, excitotoxicity blockers, immunotherapy, hormone replacement therapy and secretase effectors. Keeping the brain busy with various physical or mental exercises can reduce the onset of the disease, as the complexity of the brain’s work forces neurons to remain intact for longer.
- Subjects
ALZHEIMER'S disease; SYMPTOMS; BRAIN degeneration; CHOLINESTERASE inhibitors; ACETYLCHOLINESTERASE inhibitors; ANTIDEPRESSANTS; GLUTAMATE receptors
- Publication
Farmacist.ro, 2021, Issue 5, p16
- ISSN
1584-6539
- Publication type
Article