We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Early Aging Effect on the Function of the Human Central Olfactory System.
- Authors
Jianli Wang; Xiaoyu Sun; Yang, Qing X.; Wang, Jianli; Sun, Xiaoyu
- Abstract
During normal aging process, the smell function declines significantly, starting from the sixth decade of age. While it has been shown that activity in the central olfactory system of seniors responding to odor stimulation is significantly less than that of young people, no information of the aging effect on the functions of this system during normal adulthood and early aging has been gathered. In this study, we used functional magnetic resonance imaging to investigate the olfaction-related brain activity in the central olfactory structures of 43 healthy adult volunteers aged from 22 to 64 years. The participants' smell identification function was negatively correlated with age (r = -.32, p = .037). Significant negative correlation was observed between age and the olfaction-related activities in the bilateral dorsolateral prefrontal cortex, left insular cortex, and left orbitofrontal cortex (p < .001, corrected with cluster size ≥28 voxels). There was no significant correlation observed between age and the activity in the primary olfactory cortex detected in this age group. These results suggest that age-related functional decline in the human brain is more prominent in the secondary and higher-order central olfactory structures than the primary olfactory cortex in the early aging process.
- Subjects
AGE factors in smell; AGING; BRAIN function localization; OLDER people; PREFRONTAL cortex; INSULAR cortex; FUNCTIONAL magnetic resonance imaging; AGE distribution; BRAIN mapping; FRONTAL lobe; MAGNETIC resonance imaging; SENSORY perception; RESEARCH funding; SMELL; SMELL disorders; STATISTICS; DIAGNOSIS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2017, Vol 72, Issue 8, p1007
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glw104