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- Title
Novel synthesis of PVA/GA hydrogel microspheres based on microfluidic technology.
- Authors
Luo, Dengyu; Guo, Lin; Wang, Yuan; Wang, Pingping; Chang, Zhenqi
- Abstract
The hydrogel microspheres of polyvinyl alcohol (PVA)/ glutaraldehyde (GA) used as embolic agent can be applied in the embolization therapy. The mechanical properties and size precision of the hydrogel microspheres have a strong influence on its clinical application. In this work, the microfluidic technology was employed in the preparation of size-controlled PVA/GA hydrogel microspheres, and a novel in-situ gelation system was proposed. The influences of cross-linker (GA) content and the total content of PVA and GA in the dispersed phase, and catalyst content in the continuous phase on the compressive strength and deformation of PVA/GA gel microspheres were investigated in detail. Also, the kinetic behaviours of the formation of PVA/GA hydrogel microspheres in the microfluidic system were studied, and the results indicated that the gelation processes based on microfluidics accord to first-order reaction.
- Subjects
HYDROGELS; MICROSPHERES; POLYVINYL alcohol; GLUTARALDEHYDE; COMPRESSIVE strength; CATALYSTS; GELATION; TECHNOLOGY
- Publication
Journal of Flow Chemistry, 2020, Vol 10, Issue 3, p551
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-020-00101-w