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- Title
前列地尔联合尼莫地平对动脉瘤性蛛网膜下腔出血后脑血管痉挛患者血 管内皮功能及炎症因子水平的影响
- Authors
沈杰; 车雄宇; 高亚宏; 胡鹏; 胡卫武
- Abstract
Objective: To investigate the effects of alprostadil and nimodipine on vascular endothelial function and inflammatory factors in patients with aneurysmal subarachnoid hemorrhage (aSAH) after cerebral vasospasm (CVS). Methods: 76 cases of aSAH after CVS patients who were hospitalized in Xiangya Hospital of Central South University from March 2015 to August 2017 were selected as the research subjects, the patients were divided into the control group (n=38) and the observation group (n=38) according to the random number table method. The control group was treated with nimodipine on the basis of routine treatment, the observation group was treated with alprostadil on the basis of the control group. The average velocity of blood flow in the anterior, posterior and middle cerebral arteries of the two groups before and after treatment were compared. The changes of plasma calcitonin gene related peptide (CGRP),endothelin-1 (ET-1) and the level of serum vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), high sensitive C reactive protein (hs-CRP), tumor necrosis factor-α(TNF-α) were observed and compared, the efficacy of two groups were evaluated and the occurrence of adverse reactions in the treatment were observed. Results: Compared with the control group, the blood flow velocity of anterior cerebral artery, posterior cerebral artery and middle cerebral artery in the observation group after treatment were decreased significantly(P<0. 05). Compared with those before treatment, the level of CGRP in the two groups after treatment was significantly increased, compared with the control group, the level of CGRP in the observation group after treatment was significantly increased (P<0.05). After treatment, the levels of ET-1 and VEGF in the two groups were significantly decreased, and the observation group was lower than that in the control group (P<0.05). Compared with those before treatment, the levels of IL-8, hs-CRP and TNF-αin the two groups after treatment were significantly decreased, and compared with the control group, the levels of IL-8, hs-CRP and TNF-αin the observation group were all decreased( P<0.05). The total effective rate of the patients in the observation group was 92.11%, which was significantly higher than 73.68% of the control group (P<0.05). There was no significant difference in the incidence of total adverse reactions between the obser- vation group and the control group (P>0.05). Conclusion: The combination of alprostadil and nimodipine in the treatment of aSAH afetr CVS can significantly improve the vascular endothelial function and reduce the levels of inflammatory factors, and the adverse reaction of the drug is not increased, the treatment effect is better.
- Subjects
CEREBRAL vasospasm; CALCITONIN gene-related peptide; DRUG side effects; POSTERIOR cerebral artery; VASCULAR endothelial growth factors; ANTERIOR cerebral artery
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 5, p859
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.05.014